Much like other recent Electronic Arts game releases on PC, Mass Effect 3 will not be available through Steam. And regardless of what format you decide to get the game in — digital or physical — Origin is a requirement for playing.
In a post on the BioWare forums by community man Chris Priestly, some frequently-asked questions regarding the PC version of Mass Effect 3 (launching on March 6 for PC and consoles) were addressed. Regarding a release on Steam, it’s said that “during initial release” the digital version will be available through Origin and “a number of other 3rd party digital retailers,” Steam not being among them.